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Berberine is a SAF nutrient alkaloid reported to mimic the effects of calorie restriction and exercise on the body. It has been shown to possess powerful therapeutical properties which include activation of AMPK and inhibition of mTOR signaling concurrently with inhibition of cellular growth, increased insulin sensitivity, prevention of DNA damage, prevention of cellular senescence (aging), increased fatty acid oxidation and reduction in body fat.
Berberine is found in bark, roots, resomes and stems of certain plants including Amur Cork Tree,Tree Turmeric, OrgeonGrape, Barberry, Goldenseal, Chinese Coptis, Tinospora Cordifolia, and California Poppy.
Mechanisms of action
Recent research established that berberine activates the stress response enzyme AMPK (activated AMP protein kinase) which plays a key role in organisms’ survivability. AMPK is central to the regulation of blood sugar, energy utilization, and the control of growth and aging. Once activated, AMPK inhibits the body’s main growth pathway mTOR and thus counteract inflammation, fat gain, cholesterol buildup, cellular aging and formation of cancer cells.
AMPK is activated by calorie restriction and exercise, as well as by SAF nutrients that mimic calorie restriction and exercise. It is inhibited by excess calories, lack of exercise and deficiencies of SAF nutrients.
As an AMPK activator (and a calorie restriction and exercise mimicker), berberine has shown to coordinate metabolic programs that shift energy utilization from anabolic to catabolic pathways – from energy storage to energy expenditure – leading to increased fat oxidation, inhibition of fat synthesis and decreased body fat.
Berberine has been demonstrating health extending effects attributed to activation of AMPK and inhibition of mTOR.
- Calorie restriction and exercise like effects (increased muscle glucose uptake, increased fat oxidation, inhibition of fat synthesis, decreased body fat, decreased cholesterol, increased muscle mitochondrial biogenesis, increased insulin sensitivity)
- Anti-inflammatory (suppression of pro-inflammatory cytokines)
- Anti-aging (inhibition of mTOR; prevention of insulin resistance; suppression of cellular senescence)
- Metabolic syndrome prevention (increased fatty acid and glucose oxidation; inhibition of lipogenesis; prevention of fatty liver; increased insulin sensitivity; decreased inflammation)
- Insulin sensitizing (increased insulin receptor expression, increased glucose uptake; inhibition of gluconeogenesis; down-regulation of free fatty acids levels which are toxic to the pancreas and cause insulin resistance)
- Cholesterol lowering (lowered levels of total cholesterol, LDL and triglycerides, inhibition of cholesterol and fat synthesizing enzymes)
- Reduced body fat (energy dissipation towards fatty acid oxidation and inhibition of lipogenesis)
- Liver support (decreased hepatic fat content and prevention of fatty liver; inhibition of hepatic stellate cells (HSCs) proliferation – central to the development of liver fibrosis; inhibition of NF?ß – a major pro- inflammatory cytokine)
- Anti-neoplastic (inhibition of mTOR and growth suppression of many tumor cells; inhibition of angiogenesis; reduction in pro-inflammatory cytokines and adhesion molecules levels)
- Anti-depressant(activation of sigma receptors like many anti-depressant drugs)
- Neuro protective (prevention of neurodegenerative diseases, inhibition of cholinesterase and ß-amiloids pathways and increased brain antioxidant capacities).
- Satiety enhancement (increased level of malorylcoA in the brain)
- Increased muscle fueling efficiency( increased muscle glucose uptake; increased fat fuel oxidation)
- Increased muscle mitochondrial biogenesis (increased muscle PGC-1a expression)
Some people might be sensitive to berberine. It should not be used during pregnancy and should not be given to children.
You can now enjoy the outstanding health benefits of berberine. This bark derived nutrient has been reported to possess qualities that no other nutrient has.
Berberine turns on metabolic switches that burn fat, lower cholesterol, lower blood sugar, increase resistance to illness and stress, and even delay aging.
And it does that by activating the same pathways that are triggered during fasting and exercise. Most notable among them is the AMPK pathway. When activated by berberine, AMPK inhibits processes that make you gain fat and cholesterol, while increasing your capacity to burn fat and lose weight.
Furthermore, science has been proving that berberine has the unique capacity to block mTOR, the mechanism that when overstimulated,turns your body inflamed and sick while accelerating the aging process.
We’ve put years of research in crafting SAF strategy and making these special nutrients finally available.
Brusq, J.M., Ancellin, N., Grondin, P., Guillard, R., Martin, S., Saintillan, Y., Issandou, M. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res 47: 1281–1288, 2006.
Cha, S.H., Hu, Z., Chohnan, S., Lane, M.D. Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Proc Natl Acad Sci USA 102: 14557–14562, 2005.
Cha, S.H., Rodgers, J.T., Puigserver, P., Chohnan, S., Lane, M.D. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: role of PGC-1alpha. Proc Natl Acad Sci USA 103: 15410–15415, 2006.
Cheng, Z., Pang, T., Gu, M., Gao, A.H., Xie, C.M., Li, J.Y., Nan, F.J., Li, J. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta 1760: 1682–1689, 2006.
Hu, Z., Cha, S.H., Chohnan, S., Lane, M.D. Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci USA 100: 12624– 12629, 2003.
Kahn, B.B., Alquier, T., Carling, D., Hardie, D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15–25, 2005.
Kim, S.H., Shin, E.J., Kim, E.D., Bayaraa, T., Frost, S.C., Hyun, C.K. Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes. Biol Pharm Bull 30: 2120–2125, 2007.
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., Jiang, J.D. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 10: 1344–1351, 2004.
Lau, C.W., Yao, X.Q., Chen, Z.Y., Ko, W.H., Huang, Y. Cardiovascular actions of berberine. Cardiovasc Drug Rev 19: 234–244, 2001.
Lee, W.J., Kim, M., Park, H.S., Kim, H.S., Jeon, M.J., Oh, K.S., Koh, E.H., Won, J.C., Kim, M.S., Oh, G.T., Yoon, M., Lee, K.U., Park, J.Y. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun 340: 291–295, 2006.
Lee, Y.S., Kim, W.S., Kim, K.H., Yoon, M.J., Cho, H.J., Shen, Y., Ye, J.M., Lee, C.H., Oh, W.K., Kim, C.T., Hohnen-Behrens, C., Gosby, A., Kraegen, E.W., James, D.E., Kim, J.B. Berberine, a natural plant product, activates AMPactivated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55: 2256–2264, 2006.
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferre, P., Birnbaum, M.J., Stuck, B.J., Kahn, B.B. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569–574, 2004.
Qi, Y., Takahashi, N., Hileman, S.M., Patel, H.R., Berg, A.H., Pajvani, U.B., Scherer, P.E., Ahima, R.S. Adiponectin acts in the brain to decrease body weight. Nat Med 10: 524–529, 2004.
Turner, N., Li, J.Y., Gosby, A., To, S.W., Cheng, Z., Miyoshi, H., Taketo, M.M., Cooney, G.J., Kraegen, E.W., James, D.E., Hu, L.H., Li, J., Ye, J.M. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 57: 1414–1418, 2008.
Turnley, A.M., Stapleton, D., Mann, R.J., Witters, L.A., Kemp, B.E., Bartlett, P.F. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem 72: 1707–1716, 1999.
Viollet, B., Foretz, M., Guigas, B., Horman, S., Dentin, R., Bertrand, L., Hue, L., Andreelli, F. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 574: 41–53, 2006.
Wolfgang, M.J., Lane, M.D. Hypothalamic malonyl-coenzyme A and the control of energy balance. Mol Endocrinol 22: 2012– 2020, 2008.
Zhou, L., Yang, Y., Wang, X., Liu, S., Shang, W., Yuan, G., Li, F., Tang, J., Chen, M., Chen, J. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 56: 405–412, 2007.
Zong, H., Ren, J.M., Young, L.H., Pypaert, M., Mu, J., Birnbaum, M.J., Shulman, G.I. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 99: 15983–15987, 2002.